Table 1 Sequence conservation of positively charged amino acids on the intracellular ends of helices V, VI, and VII
From: Anionic phospholipids control mechanisms of GPCR-G protein recognition
| Â | Â | Occurrence frequency of amino acid types K, R, or H (%) | |||
|---|---|---|---|---|---|
Residue position | Amino acid type in A2AAR | 290 class A GPCRs | 290 class A GPCRs within ±1 residue | 402 non-olfactory GPCRs | 402 non-olfactory GPCRs ±1 residue |
5.60 | R | 39.6% | 41.03% | 34.57% | 40.80% |
6.32 | H | 75.5% | 88.27% | 60.19% | 70.90% |
6.35 | K | 59.3% | 64.48% | 45.77% | 64.94% |
7.56 | R | 9.3% | 11.03% | 8.46% | 14.18% |
