Fig. 6: SVEP1 and PEAR1 causally and concordantly relate to human platelet traits and cardiovascular disease.
From: SVEP1 is an endogenous ligand for the orphan receptor PEAR1
a Two-sample MR of estimated SNP effects (with 95% confidence intervals) on MPV (y-axis) and either PEAR1, green, or SVEP1, blue, in deCODE (x-axis). The causal estimate is designated by a line of the corresponding color. SVEP1 Beta = 0.018, P = 5.1 × 10−6; PEAR1 Beta = 0.11, P = 1.8 × 10−8. b Two-sample MR of estimated SNP effects (with 95% confidence intervals) on platelet count (y-axis) and either PEAR1, green, or SVEP1, blue, in deCODE (x-axis). The causal estimate is designated by a line of the corresponding color. SVEP1 Beta = −0.0075, P = 0.015; PEAR1 Beta = −0.048, P = 2.3 × 10−5. c Two-sample MR of estimated SNP effects (with 95% confidence intervals) on cardiovascular disease (y-axis) and either PEAR1, green, or SVEP1, blue, in deCODE (x-axis). The causal estimate is designated by a line of the corresponding color. SVEP1 Beta = 0.058, P = 4.5 × 10−12; PEAR1 Beta = 0.067, P = 0.0051. d Model of the vascular wall and lumen. Solid lines represent experimentally tested relationships. Dashed lines represent relationships supported by indirect evidence.
