Table 1 Descriptive summary statistics of included traits

From: Reciprocal causation mixture model for robust Mendelian randomization analysis using genome-scale summary data

Traits

Total reported sample size

Number of reported cases

Number of reported controls

Number of independent significant SNPs/loci

Variance explained by significant SNPs/loci (%)

Publication

CAD

148,172

10,801

137,371

66

21.2

Nelson et al. (2017)33

IS

440,328

34,217

406,111

2

0.6–1.8

Malik et al. (2018)34

T2D

898,130

74,124

824,006

243

18.0a

Mahajan et al. (2018)35

BirthWeight

298,142

–

–

190

7.0

Warrington et al. (2019)36

BMI

681,275

–

–

941

6.0

Yengo et al. (2018)37

BodyFat

89,297

–

–

7

0.6

Lu et al. (2016)38

Height

693,529

–

–

3290

24.6

Yengo et al. (2018)37

FastGluc

140,595b

–

–

7c

–

Lagou et al. (2021)39

FastInsulin

98,210b

–

–

1c

–

Lagou et al. (2021)39

HDL

188,577

–

–

70

1.6

Willer et al. (2013)40

LDL

188,577

–

–

57

2.4

Willer et al. (2013)40

Triglycerides

188,577

–

–

37

2.1

Willer et al. (2013)40

CRP

418,642

–

–

526

13.0

Han et al. (2020)41

CigPerDay

337,334

–

–

55

~1.1

Liu et al. (2019)42

DrinksPerWeek

941,280

–

–

99

~0.2

Liu et al. (2019)42

pulsePressure

757,601

–

–

143/62d

2.6

Evangelou et al. (2018)43

dBP

757,601

–

–

130/120d

4.5

Evangelou et al. (2018)43

sBP

757,601

–

–

183/81d

4.8

Evangelou et al. (2018)43

MDD

500,199

170,756

329,443

102e

1.5–3.2%

Howard et al. (2019)44

  1. CAD coronary artery disease, IS ischemic stroke, T2D type 2 diabetes, BirthWeight birth weight, BMI body mass index, BodyFat body fat percentage, FastGluc fasting glucose level, FastInsulin fasting insulin level, HDL high-density lipoprotein cholesterol level, LDL low-density lipoprotein cholesterol level, Triglycerides triglyceride level, CRP C-reactive protein level, CigPerDay cigarettes per day, DrinksPerWeek drinks per week, pulsePressure pulse pressure, dBP diastolic blood pressure, sBP systolic blood pressure, MDD major depressive disorder.
  2. aTrait variance explained by all GWAS SNPs/loci.
  3. bMaximum number of samples used for meta-analysis, not only European population.
  4. cDiscoveries in this study.
  5. dTwo-stage/one-stage. One-stage analysis criteria: p-value < 5 × 10−9 for the discovery meta-analysis (757,601 samples), p-value < 0.01 for UKB (458,577 samples), p-value < 0.01 for ICBP (299,024 samples) and concordant direction of effect between UKB and ICBP. Two-stage analysis criteria: genome-wide significance in the combined meta-analysis, p-value < 0.01 in the replication meta-analysis and concordant direction of effect.
  6. eFor all meta-analysis, not specific to European populations.
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