Fig. 4: Genomic atlas of all identified pQTLs. | Nature Communications

Fig. 4: Genomic atlas of all identified pQTLs.

From: Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility

Fig. 4: Genomic atlas of all identified pQTLs.The alt text for this image may have been generated using AI.

a Overview of all identified proteins excluding the participants with missing data in each protein or peptide. Each dot represents a protein/peptide-associated genetic variant. The genome-wide significant associations that should have (i) meta-analysis P < 5 × 10−8/n, where n is the number of proteins/peptides; (ii) P < 0.05 in four sub-cohorts; (iii) consistent direction of effect across the sub-cohorts. b Number of proteins identified by protein- or peptide-level data. We found 67 proteins with pQTLs in Han Chinese, three of which were based on protein-level data and 19 on peptide-level data. pQTLs protein quantitative trait loci.

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