Fig. 5: Associations between proteins and clinically relevant phenotypes. | Nature Communications

Fig. 5: Associations between proteins and clinically relevant phenotypes.

From: Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility

Fig. 5

a Colocalization of cis-pQTLs and the clinical traits. The squares represent the estimated effect size from the summary-data-based Mendelian randomization analysis, and the lines represent the 95% confidence intervals. b Effect sizes from disease GWAS studies against those from pQTL summary statistics. The orange dashed lines show the estimate at the top cis-pQTL. The error bars represent the standard errors of SNP effects. c Putative causal relationships between serum proteins and clinically relevant phenotypes. The clinical traits were obtained from GWAS summary statistics of BioBank Japan. The green represents proteins with cis-instruments, while the red represents proteins with trans-instruments. ○Praw < 0.05; *PBonferroni < 0.05. GWAS genome-wide association analysis, SMR summary-data-based Mendelian Randomization, CAD coronary artery disease.

Back to article page