Fig. 4: Loss of Pdgfd mitigates the smooth muscle cell chondrogenic transition and inflammatory pathway activation.
From: Molecular mechanisms of coronary artery disease risk at the PDGFD locus
a Bar plot showing the number of upregulated genes (58, red bars) and downregulated genes (107, blue bars) derived from all KO compared to all Ctl disease tissues. b Gene-disease network analysis of the differentially expressed genes (DEGs) among lineage traced cells in KO compared with Ctl as determined by gene set enrichment analysis with clusterprofiler, and shown as a gene-gene regulatory network with enrichplot. c Bar plot displaying numbers of DEGs in individual clusters, for KO compared with Ctl. d Heatmap showing expression patterns of downregulated DEGs across different cluster groups, based on fold-change of gene expression. Yellow color indicates differential expression, genes in red text reside in window of lead SNP ± 500 kilobases. e−h Graphs depicting gene set enrichment analysis underlying biological process of DEGs for e FMC, f CMC, g pericytes, and h CMCs as determined by clusterProfiler. Gene set enrichment analysis (GSEA) was used, with permutation test to determine adjusted p-value.
