Fig. 1: Overall architecture of the salivary gland surface protein 1 (SGS1) from Aedes aegypti. | Nature Communications

Fig. 1: Overall architecture of the salivary gland surface protein 1 (SGS1) from Aedes aegypti.

From: Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission

Fig. 1: Overall architecture of the salivary gland surface protein 1 (SGS1) from Aedes aegypti.The alternative text for this image may have been generated using AI.

a Domain diagram of SGS1. Residue numbers at domain boundaries are indicated. Two putative protease cleavage sites are shown as dashed line with scissors. Two N-glycan sites are shown as red circles. Abbreviated domain names: CBM (carbohydrate-binding module), lectin-CRD (lectin carbohydrate-recognition domain), TM (putative transmembrane helices), Tox-SGS (salivary gland secreted protein domain toxin). b Different views of the cryo-EM density map of SGS1. c Atomic model of SGS1 shown in cartoon representation. d Maximum-likelihood phylogenetic analysis of SGS1 using IQ-TREE. Targets selected for further multiple sequence alignment are labeled as red (Aedes), blue (Anopheles) and green circles (Culex).

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