Fig. 4: Putative RA-associated HLA-DR peptide-binding cores primarily consist of native sequences enriched by citrullination. | Nature Communications

Fig. 4: Putative RA-associated HLA-DR peptide-binding cores primarily consist of native sequences enriched by citrullination.

From: Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis

Fig. 4

a–c Log2 enrichment of putative binding cores (<500 nM) predicted by the NetMHCII-2.3 algorithm, denoted by the first three amino acids of the peptide core. Cores with positive values are enriched in the PAD2- or PAD4-citrullinated (cit) samples, while those with negative values are reduced by citrullination. *Denotes a uniquely created or destroyed peptide, and color-coded cores are those that contained a citrullination site. d Pie charts representing the proportion of all putative binding cores belonging to several categories (given by legend) denoting the behavior of each core in response to citrullination.

Back to article page