Table 3 Network-based in silico drug repurposing on PSC

From: Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

DrugBank id

Drug Name

Description

Indication

z

p

DB00004

Denileukin diftitox

CD25-directed cytotoxin

Cutaneous T-cell lymphoma

−5.443

2.63 × 10−8

DB05299

Keyhole limpet hemocyanin*

Immune modulator

Bladder cancer, solid tumors

−4.020

2.91 × 10−5

DB06584

TG4010*

Cancer vaccine expressing MUC1/IL2

Breast cancer, renal cell carcinoma, prostate cancer, non-small cell lung cancer.

−3.561

1.85 × 10−4

DB05304

Girentuximab*

Chimeric monoclonal antibody targeting carbonic anhydrase IX

Renal cell carcinoma

−3.526

2.11 × 10−4

DB06083

Tapinarof*

Aryl hydrocarbon receptor-modulating agent

Plaque psoriasis

−3.013

1.29 × 10−3

DB04901

Galiximab*

Anti-CD80 monoclonal antibody

Non-Hodgkin’s lymphoma, psoriasis

−2.740

3.07 × 10−3

DB00163

Vitamin E

Vitamin

Dietary supplement

−1.918

0.0276

DB06421

Declopramide*

DNA repair inhibitors

Colorectal cancer, inflammatory bowel disease.

−1.593

0.0556

DB06362

Becatecarin*

DNA intercalating agent, topoisomerase I and II inhibitor

Gastric cancer, adenocarcinoma of unknown origin, gall bladder or pancreatic tumors, breast cancer, renal cell cancer, colorectal cancer

−1.542

0.0615

DB05022

Amonafide*

DNA intercalating agent, topoisomerase II inhibitor

Breast cancer, ovarian cancer, prostate cancer, acute myeloid leukemia

−1.542

0.0616

DB08934

Sofosbuvir

N55B RNA polymerase inhibitor

Chronic hepatitis C infection

−1.342

0.0898

DB05127

ANA971*

Toll-like receptor 7

Chronic hepatitis C infection

−1.338

0.0904

DB04860

Isatoribine*

Toll-like receptor 7

Chronic hepatitis C infection

−1.338

0.0904

DB11094

Vitamin D

Vitamin

Osteoporosis prevention, Vitamin D insufficiency/deficiency, hypoparathyroidism, refractory rickets, familial hypophosphatemia

−0.515

0.3033

DB01586

Ursodeoxycholic acid

Gallstone dissolution agent

Gallstones, PBC

0.170

0.5673

  1. DrugBank id, DrugBank database identifier; Drug Name, drug name; Indication, current drug-treatment; z, relative proximity between PSC candidate genes and relevant drug of genes; p, P-value of the relative proximity. *Asterisk indicates not FDA-approved agent.
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