Fig. 5: An Anti-AD-6 antibody is non-neutralising against cell-free CMV. | Nature Communications

Fig. 5: An Anti-AD-6 antibody is non-neutralising against cell-free CMV.

From: The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread

Fig. 5

a, b Serial dilutions of anti-AD-6 pAb were incubated with Merlin (a), Merlin in the presence of complement (b) for 1 hour then used to infect HFFs (MOI = 1) and infection scored by IF for IE gene expression. Infection was expressed relative to infection in a no antibody control. c, d Serial dilutions of anti-AD-6 pAb were incubated with TB40/E (c), TB40/E in the presence of complement (d) for 1 hour then used to infect ARPE-19 cells (MOI = 2) and infection scored by IF for IE gene expression. Infection was expressed relative to infection with a no antibody control. For all experiments (a–d) n = 3 represents the mean of three independent experiments which included biological triplicates within each experiment. The error bars represent 1 standard deviation from the mean.

Back to article page