Fig. 3: Leucine mutations at W568, Y616 and F617 abolish inactivation of hERG. | Nature Communications

Fig. 3: Leucine mutations at W568, Y616 and F617 abolish inactivation of hERG.

From: Noncanonical electromechanical coupling paths in cardiac hERG potassium channel

Fig. 3

a–c are the representative current traces for the W568L, Y616L, F617L, respectively. Inset in a is the voltage protocol used. For mutant Y616L the highest voltage applied was +120 mV. Because those mutants are right shifted, we had to modify the voltage protocol used in Fig. 2a to account for the shifts. d The peak current normalized by its maximum plotted against the membrane voltage. Data are presented as mean ± SD (WT (n = 3), W568L (n = 4), Y616L (n = 6), F617L (n = 3), where n is the number of biologically independent cells).

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