Table 1 Fitted values for G-V and voltage-dependence of inactivation

From: Noncanonical electromechanical coupling paths in cardiac hERG potassium channel

 

GV

Inactivation

VG1/2

zG

VI1/2

zI

WT

−24.6 ± 0.5

2.8 ± 0.1

−61.8 ± 0.7

0.9 ± 0.1

T425L

−5.2 ± 0.4

2.6 ± 0.1

−34.8 ± 1.1

0.7 ± 0.1

P426L

N. E.

L524R

−39.6 ± 0.7

2.1 ± 0.1

−89.6 ± 1.5

0.7 ± 0.1

A527L

−30.8 ± 1.6

2.9 ± 0.5

−78.6 ± 0.6

0.9 ± 0.1

L529H

−56.7 ± 0.9

2.8 ± 0.3

−77.5 ± 1.6

0.8 ± 0.1

L532H

−33.9 ± 1.4

3.0 ± 0.4

−86.6 ± 1.5

0.6 ± 0.1

H562L

N. E.

W563L

−51.7 ± 1.0

3.3 ± 0.4

−60.7 ± 0.7

0.9 ± 0.1

A565L

N. E.

A614G

−21.2 ± 0.2

3.3 ± 0.1

−69.7 ± 2.0

1.1 ± 0.1

T618L

−18.9 ± 0.7

2.7 ± 0.2

−63.0 ± 0.7

0.9 ± 0.1

  1. N. E. No expression mutants.
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