Table 2 Free-energy of activation and inactivation evaluated for WT and all the mutant channels
From: Noncanonical electromechanical coupling paths in cardiac hERG potassium channel
Energy ΔG (kcal/mol) | ||
|---|---|---|
ΔGG (Activation) | ΔGI (Inactivation) | |
WT | −1.6 ± 0.1 | −1.2 ± 0.1 |
T425L | −0.3 ± 0.1 | −0.6 ± 0.1 |
L524R | −1.9 ± 0.1 | −1.5 ± 0.2 |
A527L | −2.1 ± 0.4 | −1.6 ± 0.1 |
L529H | −3.7 ± 0.4 | −1.4 ± 0.2 |
L532H | −2.4 ± 0.4 | −1.2 ± 0.2 |
W563L | −4.0 ± 0.5 | −1.2 ± 0.1 |
A614G | −1.6 ± 0.1 | −1.8 ± 0.1 |
T618L | −1.2 ± 0.1 | −1.3 ± 0.2 |
