Table 3 Perturbation of each mutant on the free-energy from G-V and voltage-dependence of inactivation curves
From: Noncanonical electromechanical coupling paths in cardiac hERG potassium channel
Energy ΔΔG (kcal/mol) | ||
|---|---|---|
ΔΔGG (Activation) | ΔΔGI Inactivation | |
T425L | 1.3 ± 0.1 | 0.7 ± 0.1 |
L524R | −0.4 ± 0.1 | −0.3 ± 0.2 |
A527L | −0.5 ± 0.4 | −0.3 ± 0.1 |
L529H | −2.1 ± 0.4 | −0.2 ± 0.2 |
L532H | −0.8 ± 0.4 | 0.1 ± 0.2 |
W563L | −2.4 ± 0.5 | 0.0 ± 0.2 |
A614G | 0.0 ± 0.1 | −0.6 ± 0.2 |
T618L | 0.4 ± 0.1 | 0.0 ± 0.2 |
