Fig. 8: iLN couples sympathetic signaling and type 2 immune responses to mediate cold-induced beiging of scWAT by releasing IL-33 from FRCs. | Nature Communications

Fig. 8: iLN couples sympathetic signaling and type 2 immune responses to mediate cold-induced beiging of scWAT by releasing IL-33 from FRCs.

From: Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice

Fig. 8: iLN couples sympathetic signaling and type 2 immune responses to mediate cold-induced beiging of scWAT by releasing IL-33 from FRCs.

Cold exposure enhances sympathetic innervation of iLN, thereby releasing norepinephrine (NE) to act on beta adrenergic receptors (β-ARs) in fibroblastic reticular cells (FRCs). Adrenergic stimulation induces mechanical response (contraction) of FRCs, thereby releasing IL-33 into iLN-surrounding scWAT through the efferent lymphatic vessel, and subsequently activates group 2 innate lymphoid cells (ILC2s) and their downstream type 2 immune responses for the biogenesis of beige adipocytes. Note that it is still debatable on whether and how M2 macrophages regulate cold-induced beiging in subcutaneous WAT.

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