Fig. 4: Ternary complex crystal structure of BTKKD~BCCov-cIAP1Bir3.
From: A covalent BTK ternary complex compatible with targeted protein degradation
A Cartoon depiction of BTKKD (gray), BCCov (elemental/pink), cIAP1Bir3 (salmon), cysteine 481 backbone highlighted in yellow, and a surface model (inlay). B Cysteine 481 (yellow) shows continuous electron density to BCCov at stringent 2Fo-Fc density (σ = 1.5). C Electron density at 2Fo-Fc density (σ = 1.0) surrounding BCCov. D Surface model of BTKKD (gray) and cIAP1Bir3 in unique crystallographic poses driven by 3 separate degraders; BC5P (magenta, light blue, green; 6W8I), BCPyr (orange; 6W7O), and BCCov (salmon) with a respective buried surface area at the ternary complex interface.
