Fig. 8: Optogenetic suppression during choice/outcome epoch impaired subsequent choice selection in a pathway-specific manner. | Nature Communications

Fig. 8: Optogenetic suppression during choice/outcome epoch impaired subsequent choice selection in a pathway-specific manner.

From: Distributed processing for value-based choice by prelimbic circuits targeting anterior-posterior dorsal striatal subregions in male mice

Fig. 8: Optogenetic suppression during choice/outcome epoch impaired subsequent choice selection in a pathway-specific manner.

a Schematic of surgery for pathway specific suppression and light delivery protocol for prior choice inhibition. b Changes in Win-stay (left) and Lose-stay (right) probabilities when light was ON versus OFF during choice on prior trials for PL::A-DMS circuits infected with either GFP or NpHR (black, mean ±SEM; light gray line, each animal). Yellow box indicates light delivered on prior choice epoch(GFP n = 9 animals, NpHR n = 12 animals, Šidák multiple comparison test). ***p < 0.001. c same as b, but for PL::P-DMS circuits (GFP n = 10 animals, NpHR n = 11 animals). d Schematic of surgery for pathway specific suppression and light delivery protocol for prior outcome inhibition. e Changes in Win-stay (left) and Lose-stay (right) probabilities when light was ON versus OFF after outcome on prior trials for PL::A-DMS circuits infected with either GFP or NpHR (black, mean ± SEM; light gray line, each animal). Yellow box indicates light delivered on prior outcome epoch (GFP n = 9 animals, NpHR n = 12 animals, Šidák multiple comparison test). **p < 0.01. f same as e, but PL::P-DMS circuits (GFP n = 10 animals, NpHR n = 11 animals, Šidák multiple comparison test). g Normalized number of total trials in sessions with and without outcome inhibition, where inhibition was delivered in the PL::A-DMS pathway for 30% of trials at random. Blue: NpHR; gray: GFP. of PL::A-DMS pathway in a random 30% of trials (yellow box). Solid line, mean; shaded area, ±SEM (GFP n = 9 animals, NpHR n = 12 animals). h Comparison of initiation latency (mean ±SEM) between sessions with (ON) or without (OFF) outcome epoch illumination of PL::A-DMS circuits from either GFP or NpHR group (GFP n = 9 animals, NpHR n = 12 animals). i same as g, but PL::P-DMS circuits (GFP n = 10 animals, NpHR n = 11 animals, Šidák multiple comparison test). **p < 0.01, ***p < 0.001. j same as h, but PL::P-DMS circuits (GFP n  = 10 animals, NpHR n = 11 animals, Šidák multiple comparison test). **p < 0.01.

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