Fig. 3: Biocompatibility modification of the Tm-based NPs. | Nature Communications

Fig. 3: Biocompatibility modification of the Tm-based NPs.

From: Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging

Fig. 3

a PEGylation of Tm-based NPs via hydrophobic-hydrophobic interactions between DSPE-PEG and OA-capped Tm(02Er)-NPs. Their corresponding b TEM image c DLS spectrum after PEGylation and d stability of PEGylation Tm-based NPs monitored by DLS. e DSL spectra of OA-capped Tm(02Er)-NPs in cyclohexane, Tm(02Er)-NPs@PEG and Er-NPs@PEG in water upon excitation at 800 nm. f Tm(02Er)-NPs@PEG and Er-NPs@PEG nanoparticles in vitro under 800 nm excitation (50 mW/cm2) with different filters (corresponding transmission profiles were provided in Supplementary Fig. 17). g Luminescence images of a capillary tube filled with Tm(02Er)-NPs@PEG and Er-NPs@PEG solution, immersed in various thicknesses of 1% intralipid solution recorded Er3+ or Tm3+ emissions beyond 1500 nm upon 800 nm excitation (50 mW/cm2), respectively. h Corresponding full width at half maximum (FWHM) and SBR luminescence intensity profiles. Exposure time: 50 ms.

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