Fig. 8: Mytho: a novel gene involved in the regulation of autophagy, skeletal muscle mass, and integrity. | Nature Communications

Fig. 8: Mytho: a novel gene involved in the regulation of autophagy, skeletal muscle mass, and integrity.

From: MYTHO is a novel regulator of skeletal muscle autophagy and integrity

Fig. 8: Mytho: a novel gene involved in the regulation of autophagy, skeletal muscle mass, and integrity.The alternative text for this image may have been generated using AI.

Scheme illustrating the role of MYTHO in skeletal muscle homeostasis. Acute MYTHO depletion protects from atrophy in different catabolic conditions (starvation, cancer cachexia, denervation, and sepsis). Prolonged MYTHO depletion in skeletal muscle blunts autophagic flux and triggers a sustained hyperactivation of growth signaling causing a myopathological phenotype, characterized by pathological hypertrophy, myofiber degeneration, impaired force generation, and major ultrastructural abnormalities. KD Knockdown. Created with BioRender.com.

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