Fig. 1: Biallelic DNA DSB repair at MYBPC3 locus of human embryos.
From: Limitations of gene editing assessments in human preimplantation embryos
a On-target MYBPC3 genotypes in individual blastomeres of human embryos injected with CRISPR/Cas9. b Zygosity at the target MYBPC3 locus in individual blastomeres of human embryos injected with CRISPR/Cas9. Note that a large proportion of blastomeres carried homozygous genotype locus due to LOH. c On-target LDLRAP1 genotypes in individual blastomeres of human embryos injected with CRISPR/Cas9. d Zygosity at the target LDLRAP1 locus in individual blastomeres of human embryos injected with CRISPR/Cas9. A large proportion of blastomeres with homozygous genotype demonstrates LOH at the target locus. Source Data are provided as Supplementary Data 1 and 2.
