Fig. 3: Replication values for MAGs, distribution of potentially NEC causing microbes, and specific functions. | Nature Communications

Fig. 3: Replication values for MAGs, distribution of potentially NEC causing microbes, and specific functions.

From: Clinical NEC prevention practices drive different microbiome profiles and functional responses in the preterm intestine

Fig. 3: Replication values for MAGs, distribution of potentially NEC causing microbes, and specific functions.The alternative text for this image may have been generated using AI.

a Retrieved MAGs per center, individual and time points tp1, tp3 and tp7: availability, quality, iRep replication status [min: 1.348, max: 1.998, mean: 1.654] and taxonomic placement; b Read numbers of microbial species that were correlated with NEC (Necrotizing Enterocolitis) previously, per center and per individual, MGS data. c Stacked bar plot of relative abundances of top fifteen microbiome functions per center, MGS data; d reads of ten selected differentially abundant functions per center at tp7, MGS data, n = 23 biologically independent samples: respiration: K:G q = 0.007, K:L q = 0.014, G:L q = 0.703; oxidative stress: K:G q < 0.001, K:L q < 0.001, G:L q = 0.949; osmotic stress: K:G q < 0.001, K:L q < 0.001, G:L q = 0.949; acid stress: K:G q = 0.033, K:L q = 0.029, G:L q = 0.949; fatty acids: K:G q < 0.001, K:L q < 0.001, G:L q = 0.949; phages prophages: K:G q = 0.997, K:L q = 0.640, G:L q = 0.949; pathogenicity islands: K:G q = 0.859, K:L q = 0.305, G:L q = 0.849; transposable elements: K:G q < 0.001, K:L q < 0.001, G:L q = 0.949; toxins and superantigens: K:G q = 0.005, K:L q < 0.001, G:L q = 0.760;. G in red, K in blue, L in green; significance levels are indicated with asterisks for q < 0.001 (***), q < 0.01 (**), q < 0.05 (*) for differentially abundance testing by DSeq2, adjusted for multiple comparisons. Centers are abbreviated by G (Graz), L (Leoben), and K (Klagenfurt). For boxplots, the upper, middle, and lower horizontal lines of the box represent the upper, median, and lower quartile; their whiskers depict the smallest or largest values within 1.5-fold of the interquartile range. Source data are provided as a Source Data file (see Github repository).

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