Table 1 Prophylactic regimens of probiotics, antibiotics, antifungals and feeding protocols of the three different neonatal intensive care units (NICUs): Graz (G), Klagenfurt (K), and Leoben (L)

From: Clinical NEC prevention practices drive different microbiome profiles and functional responses in the preterm intestine

Ā 

NICU Graz (G)

NICU Klagenfurt (K)

NICU Leoben (L)

Probiotics

ā€œAntibiophilusā€

Lactobacillus rhamnosus

LCR 35

1 Ɨ 109 CFU/d, oral.,

split into 2 doses per day

ā€œInfloranā€

Bifidobacterium longum subsp. infantis

NCDO 2203

2 Ɨ 109 CFU/d

Lactobacillus acidophilus NCDO 1748

2 Ɨ 109 CFU/d in combination, oral

None

Antibiotics

Gentamicin

7 mg/kg, every 12 h, oral

None

Gentamicin

7 mg/kg, every 12 h, oral

Antifungal agents

Nystatin

10,000 U/kg every 6 h, oral

Fluconazole

6 mg/kg, every 72 h (<1000 g BW), intravenous

Nystatin

10,000 U/kg every 6 h, oral

Feeding Protocol

HM favored over FM

FM and in few cases additionally pasteurized HM

HM favored over FM

  1. CFU Colony forming units, HM Human milk, FM Formula milk.