Fig. 6: RDH10 reduction-induced retinol metabolism disorder promoted cardiac lipotoxicity via atRA deficiency-mediated increases in lipid accumulation and FFAs uptake in T2DM mice (n means biologically independent animals in e, f, i, and j while n means independent experiments in h). | Nature Communications

Fig. 6: RDH10 reduction-induced retinol metabolism disorder promoted cardiac lipotoxicity via atRA deficiency-mediated increases in lipid accumulation and FFAs uptake in T2DM mice (n means biologically independent animals in e, f, i, and j while n means independent experiments in h).

From: Retinol dehydrogenase 10 reduction mediated retinol metabolism disorder promotes diabetic cardiomyopathy in male mice

Fig. 6: RDH10 reduction-induced retinol metabolism disorder promoted cardiac lipotoxicity via atRA deficiency-mediated increases in lipid accumulation and FFAs uptake in T2DM mice (n means biologically independent animals in e, f, i, and j while n means independent experiments in h).The alternative text for this image may have been generated using AI.

a Cardiac oil red O staining of RDH10-cKO mice. b Cardiac oil red O staining of db/db mice with AAV9-RDH10. c Cardiac oil red O staining of db/db mice with Rol. d Cardiac oil red O staining of db/db mice with atRA. e Cardiac TG levels of RDH10-cKO mice, n = 3, * vs RDH10fl/fl. f Cardiac TG levels of db/db mice with AAV9-RDH10, atRA, or Rol, n = 4 (db/m) and 3 (db/db, db/db-GFP, db/db-RDH10 and db/db + atRA), * vs db/m; # vs db/db; & vs db/db-GFP. g Oil red O staining of Neonatal mouse primary cardiomyocytes (NMPCs). h WB of CD36 in NMPCs, n = 4, * vs 1; # vs 2; & vs 3. i WB of cardiac CD36, n = 3, * vs db/m; # vs db/db. j Cardiac FFAs uptake capacity detection of RDH10-cKO mice and db/db mice with atRA, n = 3, * vs RDH10fl/fl (RDH10-cKO) or db/m (db/db). Data are expressed as means ± SD. Two-tailed unpaired t-test was used for the analysis of statistical significance in (e), (f) (right) and (j) (left) while one-way ANOVA with Tukey post hoc test was used for the analysis of statistical significance in (f) (left), (h), (I) and (j) (right). Source data are provided as a Source Data file.

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