Fig. 1: OTTERS framework.
From: OTTERS: a powerful TWAS framework leveraging summary-level reference data
OTTERS estimates cis-eQTL weights from eQTL summary data and reference LD panel using four imputation models (Stage I), and conducts ACAT-O test to combine gene-based association test p values from individual methods with individual/summary-level test GWAS data (Stage II).
