Table 1 Test R2 in n = 315 whole blood tissue samples from GTEx V8

From: OTTERS: a powerful TWAS framework leveraging summary-level reference data

 

P+T (0.001)

P+T (0.05)

lassosum

SDPR

PRS-CS

FUSIONb

No. of genes with \({R}^{2}\) > 0.01

9816

9662

8718

9670

10,337

4704

Median \({R}^{2}\)a

0.0440

0.0430

0.0416

0.0418

0.0517

0.0367

  1. aMedian \({R}^{2}\) among genes with test \({R}^{2} > 0.01\) per method.
  2. bFUSION was trained on GTEx V6 blood samples, while all other training methods were trained using eQTLGen summary statistics (n = 31,684) and reference LD from GTEx V8 samples.
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