Fig. 5: Schematic drawing of the transport process and conformational switching of OxlT. | Nature Communications

Fig. 5: Schematic drawing of the transport process and conformational switching of OxlT.

From: Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota

Fig. 5

The conformational landscape of OxlT along the periplasmic and cytoplasmic gate distances is shown in the top right panel. The Cα distances of the gate residues in MD simulations of the occluded and outward-open states and Gln34-induced transition are shown in red, yellow and blue, respectively. The gate-residue distances in the current occluded (PDB ID 8HPK) and outward-facing (PDB ID 8HPJ) crystal structures as well as the Nark inward-facing crystal structure (PDB ID 4U4T) are also shown.

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