Fig. 1: A subpopulation of ipRGCs in the dorsal retina. | Nature Communications

Fig. 1: A subpopulation of ipRGCs in the dorsal retina.

From: A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus

Fig. 1: A subpopulation of ipRGCs in the dorsal retina.The alternative text for this image may have been generated using AI.

a RGC axons identified in the dorsal portion of GlyT2Cre;Ai140 whole-mount retina. b, c Cre-dependent virus injection into the eyes of GlyT2Cre mice labels RGC axons that project from the dorsal retina via the optic nerve (ON) to non-image-forming central areas. d Intergeniculate leaflet (IGL; top) and suprachiasmatic nucleus (SCN; bottom; dLGN and vLGN dorsal and ventral lateral geniculate nucleus. e Confocal micrographs of melanopsin antibody staining in GlyT2Cre;Ai140 mice labeling cells with EGFP. f Current-clamp recordings of light responses to 5 s visual stimuli under the synaptic block (20 μM L-AP4, 25 μM DAP5, 20 μM CNQX) illustrate GlyT2Cre-positive RGCs are intrinsically photosensitive (ipRGCs). Similar results were obtained from eight recordings in three mice. Scale bar in a = 20 μm, c = 100 μm, d = 100 μm, e = 20 μm. Source data for panel f are provided as a source data file.

Back to article page