Fig. 1: The simulated A2AR complex with partial and full agonists that exhibited different conformational states of G proteins, in which the AHD domain was either partially or fully opened.
From: Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
a Pre-coupled complex of A2AR-Gαsβγ; A2AR in green, Gαs in cyan (AHD domain in blue), Gβ in magenta, and Gγ in yellow. b Partial agonist LUF5834-bound A2AR-Gαsβγ complex showing interfacial interaction between the A2AR and Gαs with a partially open AHD domain. c Full agonist NECA-bound A2AR-Gαβγ complex showing interfacial interaction between the A2AR and Gαs with a fully opened AHD domain. Residues of R2917.56 and R2938.48 are highlighted.
