Fig. 7: Zanidatamab mediates antitumor activity in HER2-expressing xenograft tumors.

a Mean tumor volume of patient-derived gastric xenograft model GXA 3054 implanted in nude mice. Tumor bearing mice treated with indicated test articles at 30 mg/kg, IV, twice weekly for five weeks, n = 10 per group. ***p value = 3.17e−07. b Mean tumor volume of cell-derived gastric xenograft model NCI-N87 implanted in nude mice. Tumor bearing mice treated with; single agent zanidatamab or trastuzumab at 4 mg/kg; or trastuzumab + pertuzumab combination at 4 mg/kg total (2 + 2 mg/kg of each agent), IV, twice weekly for four weeks, n = 7 per group. Statistical significance for both models was determined by fitting a linear mixed-effects model on log-transformed tumor growth data and comparing growth rates among all treatment groups, derived from the fitted model. A one-sided F-test is used as an omnibus test on the null hypothesis that all growth rates are equal. A post-hoc two-sided Tukey’s test was used to infer differences in growth rates between treatment groups and account for multiple comparisons. **p < 0.01 vs. trastuzumab or tras + pert. In a and b data are mean ± SEM. Source data are provided as a Source Data file.