Fig. 4: Transport mechanism of MmSVCT1.
From: Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter
a Structural comparison of the gate domain between inward-open MmSVCT1 (cyan) and occluded UraA (gray). b, c Movements of the core domain of the inward-open MmSVCT1 (orange or yellow) and occluded UraA (gray) viewed from the gate domain. Vitamin C and uracil are shown as purple and gray spheres, respectively. The directions of movements of the substrate (black arrows), the extracellular segments (green arrows) and intracellular segments (red arrows) of the core domain helices are indicated. d Working model for the vitamin C transport of MmSVCT1. The purple pentagons and blue spheres indicate the substrate and sodium ions, respectively.
