Fig. 3: P2X3-receptor antagonism in heart failure (HF) rats is associated with restoring autonomic balance and respiratory activity in the in situ preparation.
From: P2X3 receptor antagonism attenuates the progression of heart failure
a Raw (∫) and integrated records of thoracic sympathetic (tSN), phrenic nerve (PN), and heart rate (HR, bpm) in sham and HF rats before and after P2X3 receptor inhibition using AF-353. Note the drug was infused via a micropipette into the carotid bodies directly. In HF rats, there was increased activity of tSN and PN, associated with a reduced magnitude of respiratory sinus arrhythmia (RSA) compared to shams. Average values of b tSN, c respiratory sinus arrhythmia (RSA), and d PN frequency from sham and HF rats before and after AF-353 delivery. Data are shown as mean ± SD; n = 10 and 16 for sham and HF group, respectively. One-way ANOVA Bonferroni post-test. **P < 0.01, ***P < 0.001. Source data are provided as a Source Data file.
