Fig. 2: Clinicopathological features of mesenchymal neoplasms with DICER1 alteration.
From: Genomic characterization of DICER1-associated neoplasms uncovers molecular classes
Institutional diagnoses, tumor location, gender distribution and patient age of a LGMT DICER1, b SARC DICER1 and c PIS DICER1 (related to Supplementary Fig. 3). Black lines mark the median, edges of boxes denote interquartile range (IQR), and vertical lines indicate 1.5 × IQR. The number of independent samples is indicated. Kaplan–Meier survival curves (Kaplan–Meier estimates) indicating (d) overall survival, (e) disease specific survival and (e) progression free survival for LGMT DICER1, SARC DICER1 and PIS DICER1. Significant differences are indicated by dashed lines. g–r, Representative histological characteristics of LGMT DICER1 (g–j) showing predominantly cystic or glandular configuration with no or only sparse adjacent primitive, hypo-cellular mesenchyme, SARC DICER1 (k–n) predominantly consisting of atypical mesenchyme with variable cellularity and a mostly diffuse and patternless growth, as well as PIS DICER1 (o–r) displaying a purely mesenchymal phenotype with a markedly increased cellularity and signs of anaplasia and coagulative necrosis in a subset of tumors (related to Supplementary Fig. 4 and Supplementary Table 3). Hematoxylin & Eosin, scale bar equals 250 μm.
