Fig. 7: Late-stage diversification of bioactive compounds and pharmaceutical molecules. | Nature Communications

Fig. 7: Late-stage diversification of bioactive compounds and pharmaceutical molecules.

From: Poly(heptazine imide) ligand exchange enables remarkable low catalyst loadings in heterogeneous metallaphotocatalysis

Fig. 7: Late-stage diversification of bioactive compounds and pharmaceutical molecules.The alternative text for this image may have been generated using AI.

a Late-stage functionalization of bioactive and drug molecules. a16 h. b12 h. c36 h. dAlcohol (0.3 mmol, 1.5 eq.). eUsing elaborate phenol (estrone) as coupling partner. f72 h. gAlcohol (0.6 mmol, 3.0 eq.). h60 h. Isolated yields are given. b Gram-scale synthesis. See Fig. 6 and Supplementary Information for detailed reaction conditions and procedures.

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