Fig. 1: Adverse events, plasma cytokine dynamics, and antibody kinetics following the third vaccination.

a Summary of the cohort demographics: age, body mass index (BMI), male ratio, and comorbidities (left). HT, hypertension; DM, diabetes mellitus; DL, dyslipidemia. A cohort of healthcare workers who received two doses of BNT162b2 (n = 184) was evaluated for antibody responses, incidence of adverse events, immune cell dynamics, and cytokine/chemokine production (right). b Fold changes (Day 1 concentration/Day 0 concentration) of IL-6 and IP-10 concentrations. c Correlations between the systemic symptom severity score and IL-6 or IP-10. d receptor-binding domain (RBD)-binding IgG titers to Wuhan, Beta, and Omicron BA.1 strains in plasma were longitudinally quantified. e Relative RBD- angiotensin-converting enzyme 2 (ACE2) inhibition to Wuhan, Beta, and Omicron BA.1 strains in plasma were longitudinally quantified. For box and whisker plots, the whisker indicates minimum and maximum, and the box indicates the 25th and 75th percentiles (edges of the box), and median (center line) (a, b). The box plot indicates minimum, maximum, and median (d, e). Each dot represents the data from each individual (a–c) and dots connected with lines indicate data from the same individuals (d, e). Statistical analyses were performed using the two-tailed Mann–Whitney test (b), Spearman’s rank order coefficient (c), and Friedman test (d, e) [(b–e) *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001]. Data were pooled from ≥2 independent experiments [BNT162b2 (red), n = 90; S-268019-b (blue), n = 94]. Source data are provided as a Source Data file.