Fig. 4: Plasma antibody and Bmem responses in vaccinees without systemic adverse events. | Nature Communications

Fig. 4: Plasma antibody and Bmem responses in vaccinees without systemic adverse events.

From: Heterologous SARS-CoV-2 spike protein booster elicits durable and broad antibody responses against the receptor-binding domain

Fig. 4: Plasma antibody and Bmem responses in vaccinees without systemic adverse events.The alternative text for this image may have been generated using AI.

a Representative plots showing the analyses of IgG+ B cells binding to spike and receptor-binding domain (RBDs). Frequencies of spike+ IgG B cells (b) and RBD+ IgG B cells (c) in the B cells. Frequencies of the RBD+ IgG B cells in the spike+ IgG B cells (d) and the variants RBD+ IgG B cells in the B cells (e). For box and whisker plots, the whisker indicates minimum and maximum, and the box indicates the 25th and 75th percentiles (edges of the box), and median (center line) (b–e). Each dot represents data from individuals (b–e). Statistical analyses were performed using the Kruskal–Wallis test followed by Dunn’s post hoc test (comparisons among the different time points) or the two-tailed Mann–Whitney test [comparisons between BNT162b2 (red) and S-268019-b (blue) groups within the same time point] [(b–e) *P < 0.05 and **P < 0.01]. Data were pooled from ≥2 independent experiments [(b–e) BNT162b2: n = 19; S-268019-b: n = 19]. Source data are provided as a Source Data file.

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