Fig. 7: Schematic diagram depicting the PI3K-phospho-YBX1 proliferation axis in HNC. | Nature Communications

Fig. 7: Schematic diagram depicting the PI3K-phospho-YBX1 proliferation axis in HNC.

From: YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells

Fig. 7: Schematic diagram depicting the PI3K-phospho-YBX1 proliferation axis in HNC.

Oncogenic activation of PI3K signalling induces phosphorylation of YBX1 and nuclear translocation to promote cellular proliferation. Inactive PI3K signalling correlates with the cytoplasmic accumulation of YBX1 and the induction of EMT protein translation. The schematic was created using Biorender.com.

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