Fig. 7: Histopathology in mice lungs following vaccination with commercial influenza vaccines and subsequent challenge with H1N1 influenza virus. | Nature Communications

Fig. 7: Histopathology in mice lungs following vaccination with commercial influenza vaccines and subsequent challenge with H1N1 influenza virus.

From: Commercial influenza vaccines vary in HA-complex structure and in induction of cross-reactive HA antibodies

Fig. 7: Histopathology in mice lungs following vaccination with commercial influenza vaccines and subsequent challenge with H1N1 influenza virus.The alternative text for this image may have been generated using AI.

a–f Images show immunohistochemistry (IHC) against the influenza nucleoprotein protein for different vaccination groups. Red arrows denote viral antigen areas. Images shown are from day 3 post H1N1 challenge for all groups. a Healthy lung control via immunization with saline and challenged with saline-BSA. b Pathogenic positive control via immunization with saline with challenge with H1N1 virus. c–f Immunization with the commercial influenza vaccines c Fluzone HD, d Flucelvax, e Flublok, and f Fluad and subsequent challenge with H1N1 virus. Lung samples were collected from two mice per condition group and the experiment was replicated (N = 4). All images at 10x magnification and display 100 μm scale bars.

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