Fig. 8: Study toward the synthesis of (±)-esermethole and (±)-physostigmine. | Nature Communications

Fig. 8: Study toward the synthesis of (±)-esermethole and (±)-physostigmine.

From: 3-sulfonyloxyaryl(mesityl)iodonium triflates as 1,2-benzdiyne precursors with activation via ortho-deprotonative elimination strategy

Fig. 8

A preparation of compound 30 was realized by employing domino aryne nucleophilic-ene reaction between aryne precursor 1cc-FPs and compound 26 as the key step. After obtaining compound 27, subsequent deprotection, oxidation, N-methylation, and conversion of the enol methyl ether to aldehyde gave rise to the desired compound 30. Isolated yields are given.

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