Fig. 6: Binary roles of F356s and Q472s in channel gating.
From: Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel
Cubic chart of hydrophobic constrict sites in hEag2 closed state, viewed from the top (a) and side (b). Cubic chart of hydrophobic constrict sites in hEag2 open state, viewed from the top (c) and side (d). S5 and S6 are represented as cartoons and the remaining residues are shown in surface representation. The constrict residues, F464 and Q472, are colored in red and pink, respectively. In the open state, F464 interacts with V353 and F356 on S5 and L458 on the adjacent S6, while Q472 interacts with N466 on the adjacent S6.
