Table 1 Demographic and clinical information

From: Clinically important alterations in pharmacogene expression in histologically severe nonalcoholic fatty liver disease

 

Total

NA^

NASH Diagnosis (steatohepatitis grade)

NAS (NAFLD activity score)

Fibrosis Stage

   

0

1

2

NG*

0

1

2

3

4

5

6

7

8

NG*

0

1

2

3

4

NG*

Total

93

0

23

12

54

4

5

6

15

14

18

18

12

5

0

0

27

26

15

13

6

6

Sex

 Female

55

0

11

8

33

3

4

2

9

4

12

13

8

3

0

0

13

12

9

9

6

6

 Male

38

0

12

4

21

1

1

4

6

10

6

5

4

2

0

0

14

14

6

4

0

0

Race

 Asian

2

0

2

0

0

0

0

0

1

1

0

0

0

0

0

0

2

0

0

0

0

0

 Black

4

0

0

0

2

2

0

0

1

0

3

0

0

0

0

0

0

2

0

0

0

2

 Hispanic

1

0

0

0

1

0

0

0

0

0

0

0

1

0

0

0

0

1

0

0

0

0

 Other

2

0

1

1

0

0

0

1

0

0

1

0

0

0

0

0

2

0

0

0

0

0

 White

84

0

20

11

51

2

5

5

13

13

14

18

11

5

0

0

23

23

15

13

6

4

Concomitant Medications, yes (no)

 statins

20 (57)

16

4 (13)

0 (11)

15 (30)

1 (3)

1 (2)

2 (4)

2 (10)

2 (10)

5 (10)

4 (11)

4 (5)

0 (5)

0 (0)

0 (0)

3 (17)

5 (18)

3 (9)

4 (6)

2 (4)

3 (3)

 fishoil

9 (69)

15

1 (16)

1 (10)

7 (39)

0 (4)

0 (3)

1 (5)

0 (12)

1 (11)

2 (13)

3 (13)

2 (7)

0 (5)

0 (0)

0 (0)

2 (18)

3 (20)

1 (11)

2 (9)

0 (6)

1 (5)

 metformin

19 (58)

16

2 (15)

0 (11)

15 (30)

2 (2)

1 (2)

2 (4)

1 (11)

2 (10)

4 (11)

4 (12)

2 (6)

3 (2)

0 (0)

0 (0)

2 (18)

8 (15)

3 (9)

3 (8)

1 (4)

2 (4)

 thiazolidinediones

4 (73)

16

1 (15)

0 (11)

3 (43)

0 (4)

0 (3)

0 (5)

1 (11)

2 (10)

1 (14)

0 (17)

0 (8)

0 (5)

0 (0)

0 (0)

0 (19)

1 (22)

2 (10)

0 (12)

1 (4)

0 (6)

 vitamin E

12 (64)

17

2 (16)

2 (9)

8 (35)

0 (4)

0 (3)

1 (5)

2 (11)

3 (8)

3 (12)

1 (14)

1 (7)

1 (4)

0 (0)

0 (0)

3 (18)

6 (16)

0 (11)

3 (7)

0 (6)

0 (6)

Comorbidities,*^ yes (no)

 obesity**

69 (22)

2

12 (10)

5 (7)

48 (5)

4 (0)

2 (3)

1 (5)

11 (4)

8 (5)

15 (3)

17 (1)

10 (1)

5 (0)

0 (0)

0 (0)

12 (14)

21 (4)

13 (2)

11 (2)

6 (0)

6 (0)

 diabetes

36 (42)

15

6 (12)

1 (10)

27 (18)

2 (2)

1 (2)

2 (4)

6 (7)

2 (10)

6 (9)

10 (6)

5 (3)

4 (1)

0 (0)

0 (0)

4 (17)

11 (11)

5 (7)

7 (4)

6 (0)

3 (3)

 CAD

7 (69)

17

3 (14)

1 (9)

2 (43)

1 (3)

1 (2)

1 (4)

3 (10)

1 (10)

0 (14)

0 (16)

0 (9)

1 (4)

0 (0)

0 (0)

2 (17)

3 (20)

0 (12)

0 (10)

1 (5)

1 (5)

 hyperlipidemia

40 (35)

18

9 (7)

3 (7)

28 (18)

0 (3)

0 (2)

2 (2)

7 (6)

8 (4)

7 (8)

9 (7)

6 (2)

1 (4)

0 (0)

0 (0)

10 (8)

12 (10)

5 (8)

6 (5)

4 (2)

3 (2)

 hypothyroid

13 (63)

17

2 (15)

2 (9)

8 (37)

1 (2)

0 (2)

0 (5)

2 (11)

3 (9)

3 (12)

3 (13)

1 (8)

1 (3)

0 (0)

0 (0)

4 (16)

1 (21)

3 (9)

2 (9)

1 (5)

2 (3)

 HTN

36 (36)

21

6 (11)

1 (9)

27 (15)

2 (1)

0 (2)

0 (5)

7 (6)

5 (5)

6 (8)

10 (5)

5 (3)

3 (2)

0 (0)

0 (0)

4 (15)

16 (6)

5 (5)

5 (5)

3 (3)

3 (2)

Continuous Variables, Mean (SD)

 Weight, Kg

100 (24)

52

97 (28)

75 (13)

104 (24)

93 (9)

87 (NA)

86 (NA)

86 (15)

93 (6)

97 (28)

109 (27)

94 (10)

130 (41)

NA

NA

96 (29)

95 (12)

130 (34)

107 (29)

83 (20)

89 (6)

 Age

50 (13)

0

49 (14)

50 (15)

50 (12)

50 (15)

61 (3)

49 (14)

51 (12)

48 (12)

46 (13)

50 (13)

53 (13)

48 (9)

NA

NA

48 (12)

49 (15)

51 (12)

49 (10)

59 (8)

49 (13)

 BMI

32 (9)

4

32 (5)

26 (10)

34 (10)

34 (3)

32 (5)

27 (4)

32 (5)

28 (9)

31 (9)

36 (11)

31 (10)

41 (8)

NA

NA

30 (8)

32 (8)

33 (12)

36 (8)

29 (15)

35 (3)

 alt

70 (45)

5

53 (27)

51 (36)

81 (50)

67 (35)

58 (37)

55 (39)

46 (21)

63 (59)

60 (46)

84 (32)

101 (55)

97 (41)

NA

NA

55 (32)

84 (58)

89 (50)

53 (21)

68 (53)

66 (27)

 platelets

237 (82)

13

224 (79)

246 (51)

245 (90)

194 (17)

184 (61)

204 (69)

247 (87)

218 (66)

232 (68)

240 (57)

282 (134)

238 (76)

NA

NA

222 (77)

229 (64)

272 (120)

232 (42)

289 (145)

205 (33)

  1. *NG = Not graded, not staged, not scored.
  2. ^NA = not available, missing data, unknown.
  3. **BMI > 30, or per medical history.
  4. *^The presence of these comorbidities is based on a combination of medical history and medication use in their medical records. For example, if someone is on sulfonylureas we assigned them as having diabetes. Similarly, if someone is taking a statin, then hyperlipidemia is identified, etc.
Back to article page