Table 2 Bonferroni-adjusted significant linear regression correlation estimates between disease sub-groups and pharmacogenes
Gene | Slope | Unadjusted p value | R-squared | Adjusted p value (Bonferroni) | Disease sub-group |
|---|---|---|---|---|---|
ABCB4 | 0.14 | 1.77E-10 | 0.36 | 4.51E-08 | NAS |
GSS | 0.05 | 6.46E-08 | 0.28 | 1.65E-05 | NAS |
SLC22A12 | 0.52 | 7.92E-08 | 0.27 | 2.02E-05 | NAS |
MAT1A | −0.06 | 2.11E-06 | 0.22 | 5.37E-04 | NAS |
PON3 | −0.08 | 2.94E-06 | 0.21 | 7.50E-04 | NAS |
DHRS7B | 0.05 | 4.64E-06 | 0.21 | 1.18E-03 | NAS |
FMO1 | 0.28 | 2.22E-05 | 0.18 | 5.67E-03 | NAS |
ALDH6A1 | −0.08 | 2.92E-05 | 0.18 | 7.45E-03 | NAS |
ABCB8 | 0.06 | 4.55E-05 | 0.17 | 1.16E-02 | NAS |
GSR | 0.05 | 5.89E-05 | 0.16 | 1.50E-02 | NAS |
DHRS9 | 0.17 | 1.10E-04 | 0.15 | 2.80E-02 | NAS |
SLC16A1 | −0.10 | 1.19E-04 | 0.15 | 3.04E-02 | NAS |
AOX1 | −0.06 | 1.43E-04 | 0.15 | 3.66E-02 | NAS |
ABCC3 | 0.07 | 1.85E-04 | 0.14 | 4.72E-02 | NAS |
GSTZ1 | −0.17 | 5.51E-09 | 0.33 | 1.40E-06 | Fibrosis |
SLCO3A1 | 0.24 | 7.34E-09 | 0.33 | 1.87E-06 | Fibrosis |
ABCC4 | 0.27 | 3.33E-07 | 0.27 | 8.50E-05 | Fibrosis |
MAT1A | −0.09 | 3.76E-07 | 0.26 | 9.60E-05 | Fibrosis |
GSTP1 | 0.20 | 7.95E-07 | 0.25 | 2.03E-04 | Fibrosis |
CYP2C19 | −0.37 | 1.90E-06 | 0.24 | 4.85E-04 | Fibrosis |
CHST9 | 0.22 | 2.23E-06 | 0.23 | 5.68E-04 | Fibrosis |
GPX7 | 0.24 | 2.96E-06 | 0.23 | 7.54E-04 | Fibrosis |
SLC28A3 | 0.35 | 3.28E-06 | 0.23 | 8.35E-04 | Fibrosis |
SOD3 | 0.36 | 5.62E-06 | 0.22 | 1.43E-03 | Fibrosis |
CFTR | 0.40 | 9.04E-06 | 0.21 | 2.31E-03 | Fibrosis |
PDE3A | 0.24 | 1.56E-05 | 0.20 | 3.98E-03 | Fibrosis |
SLC2A4 | −0.24 | 1.67E-05 | 0.20 | 4.26E-03 | Fibrosis |
DHRS7B | 0.08 | 2.26E-05 | 0.19 | 5.75E-03 | Fibrosis |
ABCC1 | 0.22 | 2.71E-05 | 0.19 | 6.92E-03 | Fibrosis |
ALDH3B1 | 0.14 | 2.86E-05 | 0.19 | 7.28E-03 | Fibrosis |
CYP1B1 | 0.15 | 4.35E-05 | 0.18 | 1.11E-02 | Fibrosis |
SLC22A17 | 0.19 | 6.17E-05 | 0.17 | 1.57E-02 | Fibrosis |
CHST4 | 0.33 | 6.28E-05 | 0.17 | 1.60E-02 | Fibrosis |
HSD17B14 | −0.26 | 6.45E-05 | 0.17 | 1.65E-02 | Fibrosis |
SLC6A6 | 0.23 | 7.07E-05 | 0.17 | 1.80E-02 | Fibrosis |
CHST10 | 0.27 | 1.29E-04 | 0.16 | 3.30E-02 | Fibrosis |
CHST3 | 0.20 | 1.35E-04 | 0.16 | 3.45E-02 | Fibrosis |
ALDH1A3 | 0.23 | 1.40E-04 | 0.16 | 3.58E-02 | Fibrosis |
MAT1A | −0.14 | 2.28E-07 | 0.27 | 5.81E-05 | Steatohepatitis |
CHST9 | 0.31 | 4.18E-06 | 0.22 | 1.07E-03 | Steatohepatitis |
CYP2C19 | −0.50 | 5.98E-06 | 0.21 | 1.53E-03 | Steatohepatitis |
PON3 | −0.16 | 3.44E-05 | 0.18 | 8.77E-03 | Steatohepatitis |
GSS | 0.09 | 5.04E-05 | 0.17 | 1.29E-02 | Steatohepatitis |
ABCB4 | 0.21 | 5.78E-05 | 0.17 | 1.47E-02 | Steatohepatitis |
SLCO3A1 | 0.24 | 1.34E-04 | 0.16 | 3.42E-02 | Steatohepatitis |
AOX1 | −0.13 | 1.70E-04 | 0.15 | 4.35E-02 | Steatohepatitis |
