Fig. 2: MIER1 targets and regulates cell cycle gene expression through chromatin remodeling. | Nature Communications

Fig. 2: MIER1 targets and regulates cell cycle gene expression through chromatin remodeling.

From: Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice

Fig. 2

a Genomic distribution of MIER1 binding sites. b Gene enrichment analysis of genes bound by liver MIER1. Numbers of genes in each GO term are shown. c Gene enrichment analysis of genes both bound by MIER1 and up-regulated in Mier1-depleted liver tissue. d Overlapped peaks of liver MIER1 with increased ATAC-seq peaks at 24 h post-surgery as compared to ones before surgery (above); Gene enrichment analysis of genes near these overlapped peaks (below). e Average intensity of ATAC-seq signals of the overlapped 2221 peaks as in (d) surrounding the transcription start site (TSS) in Control and Mier1 sgRNA groups at 24 h post hepatectomy. f Liver ATAC-seq tracks and MIER1 signals near cell cycle-relevant genes at 24 h after surgery in different groups as indicated. P values were assessed by two-tailed Fisher’s exact test (b, c, e).

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