Fig. 6: Acute HFD treatment improves liver regeneration. | Nature Communications

Fig. 6: Acute HFD treatment improves liver regeneration.

From: Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice

Fig. 6

a Schematic presentation of acute HFD (acHFD) treatment. The liver TG content (b) (n = 8, 9, 8, 7 in Control group, and n = 8, 9, 7, 8 in acHFD group, in different time points after PHx), and liver immunoblots of MIER1 and EIF2S1 phosphorylation (c) (n = 3) in Control or acHFD animals before or after hepatectomy. The liver/body weight ratio (%) (d) (Control, n = 7; acHFD, n = 8; acHFD; Mier1 sgRNA, n = 8), liver Ki-67 staining (e) (n = 7), and liver immunoblots (PCNA, Cyclin A2 and GAPDH) (f) in Control, acHFD, and acHFD; Mier1 sgRNA animals at 36 h after hepatectomy. Values represent means with SEM. P values were assessed by Two-way ANOVA with post hoc Šídák’s multiple-comparison tests (b, c), or One-Way ANOVA with Dunnett’s multiple comparisons test (d, e). The experiment was repeated for four times with similar results (f). The average values of the quantification of western blots were indicated (f). Source data are provided as a Source Data file.

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