Table 3 Virus Yield Reduction Data for Compound 7 Against Three Variants of SARS-CoV-2 in Caco-2 Cells
From: Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
Strain | Compound | EC90a (μM) | CC50b (μM) | SI90c |
|---|---|---|---|---|
USA-WA1/2020 | 7 | 0.26 | >10 | >38 |
EIDD-1931 | 0.12 | 94 | 780 | |
Delta (B1.617.2) | 7 | >10 | >10 | 0 |
EIDD-1931 | 4.9 | >100 | >20 | |
Omicron (B1.1.529) | 7 | 2.4 | >10 | >4.2 |
EIDD-1931 | 2.9 | >100 | >34 |
