Fig. 5: Synthesis of Kishi and Eisai intermediates 46 and 3.
From: An α-chloroaldehyde-based formal synthesis of eribulin
Exploiting the Corey–Chaykovsky coupling and Ti(III)-promoted rearrangement sequence, synthesis of the known acetonide- and TBS-protected diols 46 and 3 was accomplished. Cp cyclopentadienyl.
