Fig. 7: State dependent global spatiotemporal patterns of SWRs in AW and NREM states using neural-event-triggered (NET) fMRI.
From: Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice
a SWR-triggered BOLD responses in AW (12732 epochs) and NREM (10953 epochs) states. The number of event epochs were counted under the sampling rate of 0.5 Hz (fMRI repetition time) in the following analysis. Results in the axial view were shown in Supplementary Fig. 17, 18. b Major brain divisions on 3D surface viewing as in (a). Abbreviations of ROIs were listed in Supplementary Data 1. c, d Significant difference of SWR-triggered BOLD responses in mPFC between AW and NREM states (c) and its corresponding electrophysiological correlates (d). Gray lines (or shadows), mean (+/− SEM.) correlation. Sample size: n = 16 sessions. e Overlap of SWRs and spindle events in NREM state. f Spindle-uncoupled (4682 epochs) and coupled (6271 epochs) SWR-triggered BOLD responses in NREM state. Results in the axial view were shown in Supplementary Fig. 21, 22. g, h Significant difference of BOLD responses in mPFC between spindle -uncoupled and -coupled SWRs in NREM state (g) and its corresponding electrophysiological correlates (h). Colored lines (or shadows), mean (+/− SEM.) correlation. Sample size: n = 16 sessions. i No significant difference of event evoked BOLD signals in mPFC between awake SWRs and spindle-uncoupled SWRs. Each dot represented an individual session. mPFC, medial prefrontal cortex. Error bars, standard errors of the mean. Statistical significance was calculated by two-tailed t-test. Source data are provided as a Source Data file.
