Table 1 Test of stabilizing selection of the mutation rate in yeast.

From: Author Correction: The rate and molecular spectrum of mutation are selectively maintained in yeast

 

Vm

VmL

VmH

 

Vm1

Vm2

Vm3

VmL1

VmL2

VmL3

VmH1

VmH2

VmH3

CAN1-based tests (Vg: 4.5 × 10-2)

 Mutational variance

5.4 × 10-6

9.7 × 10-7

3.5 × 10-5

4.4 × 10-6

7.9 × 10-7

2.8 × 10-5

9.5 × 10-7

1.7 × 10-7

6.1 × 10-6

 Vg/Vm (neutral expectation: 4 × 107)

8.3 × 103 ¶

4.6 × 104¶

1.3 × 103¶

1.0 × 104¶

5.7 × 104¶

1.6 × 103¶

4.7 × 104 ¶

2.6 × 105 ¶

7.3 × 103¶

MA+WGS-based tests (D2: 0.18)

 Mutational variance

3.6 × 10-6

6.5 × 10-7

2.3 × 10-5

1.3 × 10-7

2.4 × 10-8

8.5 × 10-7

2.2 × 10-6

4.0 × 10-7

1.5 × 10-5

 D2/Vm (neutral expectation: 2.89 × 109)

5.0 × 104 ¶

2.8 × 105¶

7.8 × 103¶

1.4 × 106*

7.7 × 106*

2.2 × 105*

8.2 × 104¶

4.5 × 105¶

1.3 × 104¶

  1. All mutation frequencies/rates are log10-transofrmed before the test. CAN1-based intraspecific mutation rate variance Vg is from 7 natural strains while Vm is from 48 MA lines. MA+WGS-based D2 is the squared difference in SNV mutation rate between S. cerevisiae and S. paradoxus, while Vm is based on the SNV mutation rates of 13 MA lines. All Vg/Vm and D2/Vm ratios are significantly below the corresponding neutral expectations based on bootstrap tests (*P < 0.05; P < 0.0001).
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