Fig. 5: Activity of NITD609 and TD-6450 on asexual parasites.
From: Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening
A Giemsa-stained erythrocytes infected by a ring-stage of P. falciparum exposed to DMSO (negative control, green border), TD-6450 5 µM (blue border) and NITD609 1 µM (red border). The optical microscopic observations were repeated 5 times. B Dose-response of synchronized ring-stage P. falciparum (NF54 and 3D7 pULG8-GFP strains), exposed for 48 h to TD-6450 (blue) and NITD609 (red). C Dose-response of F32-TEM strain either before (dark blue), or after 5 (blue) or 10 (light blue) drug pulses with TD-6450. Each point shows the mean (±SD) of 3 replicates. Source data are provided as a Source Data file.
