Fig. 3: DCFHP-alum immunized NHPs elicit cross-reactive neutralizing responses. | Nature Communications

Fig. 3: DCFHP-alum immunized NHPs elicit cross-reactive neutralizing responses.

From: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Fig. 3: DCFHP-alum immunized NHPs elicit cross-reactive neutralizing responses.

A Immunization scheme for NHPs immunized in either group A or group B with a 50 µg dose of DCFHP formulated with 750 µg alum (SI Table 2). Arrows indicate days of immunization. B Pseudoviral neutralization (plotted as the log of the neutralizing titer (reciprocal serum dilution)) of Wuhan-1 SARS-CoV-2 from NHP serum obtained 21 days following initial immunization are similar between groups A and B. C Cross-reactive pseudoviral neutralization by serum from NHPs isolated 14 days post boost. Means and standard deviations for biological replicates are plotted and noted for each animal (n = number of replicate neutralization assays conducted for these samples on independent days). D As in panel (C) for group B. E Limited dilution, neutralization values for authentic SARS-CoV-2 VOCs for serum samples obtained 14 days post-boost. NHP identification provided correlate with SI Table 1. Assay limits of quantitation indicated by horizontal dotted line. n is defined as individual replicates of the experiment, GMT and STD are shown.

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