Fig. 4: DCFHP-alum immunized NHPs elicit long-lived immunity against both Wuhan-1 and BA.4/5 pseudoviruses. | Nature Communications

Fig. 4: DCFHP-alum immunized NHPs elicit long-lived immunity against both Wuhan-1 and BA.4/5 pseudoviruses.

From: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Fig. 4: DCFHP-alum immunized NHPs elicit long-lived immunity against both Wuhan-1 and BA.4/5 pseudoviruses.

A Serum neutralizing titers were monitored over 337 days against Wuhan-1 SARS-CoV-2 pseudovirus for animals in group A; days of prime and boost indicated with arrows. B As in panel (A) but against BA.4/5 pseudovirus. C, D As in panels (A) and (B) but with group B NHPs, respectively. Averages and standard deviations for replicate neutralization assays are shown; for panels A–D: n = 3, n = 4, n = 2, and n = 3, respectively (n = number of replicate neutralization assays conducted for these samples on independent days). NHP identification provided correlate with SI Table 1. Assay limits of quantitation indicated by horizontal dotted lines.

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